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This is the date at which the manufacturer can still guarantee the full potency and safety of the drug. Most of what is known about drug expiration dates comes from a study conducted by the Food and Drug Administration at the request of the military.
With a large and expensive stockpile of drugs, the military faced tossing out and replacing its drugs every few years. So, the expiration date doesn't really indicate a point at which the medication is no longer effective or has become unsafe to use. Medical authorities state if expired medicine is safe to take, even those that expired years ago.
A rare exception to this may be tetracycline, but the report on this is controversial among researchers.
It's true the effectiveness of a drug may decrease over time, but much of the original potency still remains even a decade after the expiration date. Excluding nitroglycerin, insulin, and liquid antibiotics, most medications are as long-lasting as the ones tested by the military.
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Placing a medication in a cool place, such as a refrigerator, will help a drug remain potent for many years. Is the expiration date a marketing ploy by drug manufacturers, to keep you restocking your medicine cabinet and their pockets regularly? You can look at it that way.
Or you can also look at it this way: The expiration dates are very conservative to ensure you get everything you paid for. And, really, if a drug manufacturer had to do expiration-date testing for longer periods it would slow their ability to bring you new and improved formulations.
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